Gregory JM. De Crescenzo
GRSTB Regular MemberÉcole Polytechnique
Assistant Professor
chemical engineering
Coordinates:
| Phone Number: | 514 340 4711 ext.: 7428 |
| Fax: | 514 340 2990 |
| Email: | gregory.decrescenzo@polymtl.ca |
| Office: | JAB 2084 |
| Postal Address: | C.P. 6079 succ. Centre-ville Montréal, Québec H3C 3A7 Montréal (Québec) Canada |
Research:
| Title: | Protein-enhanced Biomaterials / Biosensors |
| Description: | Within the same tissue, the various growth factor and receptor systems that exist regulate interactions between that tissue’s cells. These functions are usually regulated by complex mechanisms involving variations in molecules’ concentration and type of interaction. Despite remarkable advances in recent years, regenerative medicine still faces a lot of challenges. One of them is to improve the configuration of molecular processes connected with cell growth and differentiation. And this, in particular, requires a better understanding of growth-factor-related requirements. Drawing on the expertise of other researchers, we are looking to optimize the immobilization of growth factors on the surface of new polymers, taking a new approach based on the use of synthetic peptides. This approach will let us unite the properties of the new materials with the very specific features of the growth factors to promote rapid, controlled tissue regeneration. |
| Axes of Biomedical Applications: | CardiovascularBiosensors SPR |
| Technological Approaches: | Biomaterials, Nanotechnology and microsystems |
| Expertise: | Drug Delivery, Protein Engineering, Macromolécular Interactions, facteurs de croissance, In vitro Cell Assays, Protein Grafting, SPR Biosensors, Kinetics / Affinity Measurements |